Posts

Abstract - 2018 - Research and Practice in Thrombosis and Haemostasis

Image
purpura bleeding :: Article Creator Clinical Decision-Making In ITP: Timing Treatment Initiation And Therapy Goals An expert discusses treatment strategies for immune thrombocytopenic purpura (ITP), emphasizing individualized decisions based on platelet count, bleeding symptoms, and comorbidities, with options ranging from observation to urgent therapies like steroids or IVIG, and longer-term approaches tailored to patient health, treatment goals, and lifestyle considerations. Once immune thrombocytopenic purpura (ITP) is diagnosed and other causes of thrombocytopenia have been excluded, treatment decisions depend on the patient's platelet count, symptoms, and comorbidities. If a patient has a platelet count above 20,000 to 30,000 without active bleeding, treatment may not be necessary—close monitoring might be sufficient. However, if there is any evidence of bleeding (e.G., nosebleeds, hemorrhoid-related bleeding, or petechiae), treatment...

Anemia in the pediatric patient

Image
epp blood disease :: Article Creator Czechia To Overhaul Preventive Check-ups With Expanded Lab Tests Selected testing will be repeated at an advanced age to track potential changes. [Getty Images] The Czech Health Ministry prepared an amendment to the decree on preventive examinations to better tailor check-ups to patients' age and risk profile. The aim is to detect or prevent diseases earlier while keeping the service fully covered by public health insurance. Czech Health Minister Vlastimil Válek (TOP 09, EPP) says the overhaul of preventive check-ups comes "after decades". "The check-ups will have a different content, more targeted to sex, the age of the patient and his comorbidities; they will focus far more on cardiovascular and other diseases," he said. The ministry says the revision responds to feedback from the professional community and to the changing health status of the population. Preventive visits should...

Anemia in the pediatric patient

Image
vwd doberman :: Article Creator A Vet's Guide To Von Willebrand Disease In Dogs When you buy through links on our articles, Future and its syndication partners may earn a commission. Credit: Getty Images/ bluecinema Von Willebrand disease in dogs is the most common inherited blood disorder our canine friends suffer with, and it also happens in humans and many other species. It's a bleeding disorder – a failure of the blood to clot – with symptoms that can vary from mild to severe. Luckily, von Willebrand Disease is rare enough that I haven't had to deal with many dogs with the disorder in my eight years of being a vet, but I still keep a close lookout for it. In this article, I'll explain what von Willebrand Disease is and – if your dog is unlucky enough to have it – what the likely outcome will be. Just to reassure you though, that the most common form of von Willebrand disease in dogs is mild and has a near-normal life ex...

Bone fragility in patients affected by congenital diseases non skeletal in origin

Image
hemophilia common bleeding sites :: Article Creator Bleeding, Damage Common In Pediatric Hemophilia Despite Prophylaxis Although prophylaxis is the gold standard of treatment for children with hemophilia, a new report highlights the need to vigilantly monitor patients for signs of "hidden" joint damage. The ankles are an area of particular concern, according to the authors of a new study published in Thrombosis Research. Hemophilic arthropathy is the most common complication of hemophilia, wrote the study authors. In many cases, arthropathy leads to disability and diminished quality of life. Primary prophylactic infusion of coagulation factor is used to prevent joint bleeding and bone damage. However, despite prophylaxis, some patients still develop joint damage, suggesting that subclinical bleeding is relatively common. "It usually manifests as joint discomfort, which disappears with the new dose of replacement factor...

Adeno-associated virus as a delivery vector for gene therapy of human diseases

Image
genetic testing for thalassemia :: Article Creator Research Improves Diagnosis Of Genetic Blood Disorder Beta-thalassemia Doctors examine biomarkers in blood to determine health status. These molecules can indicate if any abnormal processes are taking place, which could point to a disease. However, the process behind blood measurements is highly complex and the results can vary considerably between different methods and laboratories. This poses a major challenge for diagnosis or therapeutic intervention. To help standardize blood tests carried out by laboratories, the JRC develops clinical certified reference materials (CRMs). These control materials form the basis for reliable and stable clinical measurements. A CRM typically comes in a "bottle," a sample with a known quantity of what is being measured, like a gold standard for laboratory tests. When laboratories use these CRMs, they can be confident that their results are correct a...

Abstract - 2018 - Research and Practice in Thrombosis and Haemostasis

Image
cerebral circulation disorders :: Article Creator Can CRISPR Fix A Childhood Brain Disorder? When brain development gets off to a bad start, the consequences are lifelong. One example is a condition called SCN2A haploinsufficiency, in which children are born with just one functioning copy of the SCN2A gene — instead of the normal two. They develop defects in the connections, or synapses, between some of their brain cells that affect how well they can send signals. As a result, they do not learn to speak, and many of them experience seizures. Now, scientists at UC San Francisco have used a version of the gene-editing technology CRISPR to ameliorate some of these problems in mice, which can be engineered to carry the same mutation that humans do. But rather than trying to edit the defective copy of the gene, the scientists just turned up the volume on the healthy one. The procedure worked in mice that were roughly equivalent in age to 10-year-ol...

Anemia in the pediatric patient

Image
48xx syndrome :: Article Creator