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Showing posts from August, 2025

Abstract - 2018 - Research and Practice in Thrombosis and Haemostasis

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sickle cell haemoglobin :: Article Creator Researchers Say Deadly Twist Key To Sickle Cell Disease Patients with sickle cell disease have mutant haemoglobin proteins that form deadly long, stiff fibres inside red blood cells. A research team led by University of Warwick researcher Dr Matthew Turner, propose a mathematical model in the 28 March online issue of PRL to explain the persistent stability of these deadly fibres. The theory suggests that an inherent "twistiness" in the strands that make up the fibres could be the key to their durability and possibly to new treatments. Red blood cells supply oxygen to the body using their cargo of haemoglobin, a protein that can capture and release oxygen. Haemoglobin molecules normally float freely in the cell, but sickle cell patients have a mutated, "sticky," form of haemoglobin that tends to clump together into long fibres. The stiff fibres form a scaffolding that distorts the cells i...

Rare inherited coagulation and fibrinolytic defects that challenge diagnostic laboratories

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small blood vessel disease brain :: Article Creator Mild Chronic Small Vessel Disease Ups Risk For DementiaEntertainment ... What is mild chronic small vessel disease? Mild chronic small vessel disease, or cerebral small vessel disease (CSVD), is an umbrella term for a range of conditions caused by damage to small blood vessels in the brain. An estimated 11 million Americans are living with CSVD, with a 25% chance of strokes caused by the condition and 45% of dementia cases caused by CSVD. CSVD usually results from the narrowing or blockage of the brain vessels due to inflammation, hardening of the arteries, plaque buildup or the thickening of the vessel walls. Consistent and ongoing damage to the brain's blood vessels deprives cells of oxygen and can cause permanent deterioration and dysfunction. Some earlier signs and symptoms of the condition may go unnoticed as symptoms become more severe at later stages of the disease after more...

Anemia in the pediatric patient

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types of congenital hearing loss :: Article Creator Lisa Jarvis: A Cure For Some Kinds Of Hearing Loss? Gene Therapies Are ... To place an obituary, please include the information from the obituary checklist below in an email to obits@pioneerpress.Com. There is no option to place them through our website. Feel free to contact our obituary desk at 651-228-5263 with any questions. General Information: Your full name, Address (City, State, Zip Code), Phone number, And an alternate phone number (if any) Obituary Specification: Name of Deceased, Obituary Text, A photo in a JPEG or PDF file is preferable, TIF and other files are accepted, we will contact you if there are any issues with the photo. Ad Run dates There is a discount for running more than one day, but this must be scheduled on the first run date to apply. If a photo is used, it must be used for both days for the discount to apply, contact us for more information. Pol...

Anemia in the pediatric patient

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atherosclerotic and hypertensive cardiovascular disease :: Article Creator Could Atherosclerosis Already Be Clogging Your Arteries? - WebMD Ever wish you could see inside your arteries? These blood vessels deliver oxygen-rich blood to every corner of our bodies. Maintaining the flow is essential to life and health. Atherosclerosis causes narrowing and hardening of the arteries, creating slowdowns in blood flow. Even worse, atherosclerosis can trigger sudden blood clots. Heart attacks and strokes are the often-deadly result. If we could see what was going on in our arteries, we might think twice about our lifestyle choices. Could atherosclerosis be clogging your arteries? Take a look on this amazing voyage into your body's highway system. The entire body depends on arteries for blood flow. Atherosclerosis acts throughout the body but is more selective as to where it becomes serious. "One of the paradoxes of atherosclerosis is that ...

How I diagnose and treat neonatal thrombocytopenia

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diabetes and low platelet count :: Article Creator Red Blood Cells 'Talk' To Platelets, With Implications For Diabetes Amid growing indications that the traditional image of red blood cells (RBCs) falls short of reality, chemists are reporting evidence that RBCs are key participants in a communication system among cells in the bloodstream. Messaging between RBCs and platelets (blood components that cause clotting) they say, could explain the effects of a drug suggested for use in preventing heart attacks and other complications of diabetes. In a study scheduled for the July 13 issue of ACS' Analytical Chemistry, a semi-monthly journal, Dana Spence and colleagues note that RBCs once were regarded mainly as oxygen carriers. Recent research, however, shows that red cells also release ATP, a molecule that is the source of energy for all life processes, as they deform while they travel through small blood vessels. By observing blood flow ...

Rare inherited coagulation and fibrinolytic defects that challenge diagnostic laboratories

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diseases caused by chromosomal abnormalities :: Article Creator Model Explains Disorders Caused By Improper Transmission Of Chromosomes Parents of healthy newborns often remark on the miracle of life. The joining of egg and sperm to create such delightful creatures can seem dazzlingly beautiful if the chromosome information from each parent has been translated properly into the embryo and newborn. The darker side is that when extra copies of chromosomes or fewer than the normal 46 (23 from each parent) are present, tragic birth defects can occur. Now, scientists at the University of Georgia have developed a model system for plants and animals that shows the loss of a key structural protein can lead to the premature separation of one DNA copy called a chromatid. The new model shows for the first time that the loss of this protein can lead to aneuploidy—the name given to birth disorders caused by extra or too few chromosomes. Disorders caused by err...

Anemia in the pediatric patient

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low platelet and wbc count :: Article Creator What Causes Thrombocytopenia (low Platelet Count)? Key takeaways Thrombocytopenia, or a low platelet count, can impair blood clotting, potentially leading to severe bleeding from wounds. Underlying health conditions like autoimmune diseases and cancers, as well as medications and substances such as alcohol, can cause thrombocytopenia. While mild cases may not require treatment, symptomatic thrombocytopenia may require a change in medication or treatment of the underlying condition. A reduced platelet count in the blood is not always a serious problem. However, the condition affects the blood's ability to clot. If a person's blood does not clot, a wound may bleed severely. This can have serious complications in some cases. This article examines the conditions, medications, and substances that can cause a low platelet count. It also outlines how to recognize the sympt...