ASXL1 Mutations Associated With Worse Prognosis in MDS and AML

Y Combinator

Luca, a startup building price planning and prediction tools for retailers, today announced that it closed a $2.5 million seed round led by Menlo Ventures with participation from Y Combinator (Luca wa

Sitting through hundreds of startups on YC Demo Days, you're not always sure whether you are actually perceiving patterns or if your brain, as coffee battles with monotony, is inventing them in

If you add up the fact that rival accelerators 500 Startups and Techstars have given up on their Stockholm programs, a pattern starts to emerge.

Hello, and welcome back to Equity, a podcast about the business of startups, where we unpack the numbers and nuance behind the headlines. This was Y Combinator week in a sense, with the well-known ac

Over 20,000 applications flew into Y Combinator, which ended up plucking out 282 startups for its latest batch. Now we're getting our first look at them through Demo Day. The first day's demos inc

Here's a crazy statistic: More than half of the companies in Y Combinator's latest cohort were accepted to the accelerator with only an idea, no minimum viable product or revenue strategy needed.

Y Combinator, the startup accelerator that has launched the likes of Instacart, Stripe and Airbnb, has broadened its investing lens in recent years, backing companies all over Africa and India, and be

Spencer Levitt and Austin Pager met early on as classmates at Northwestern University and spent the next several years building apps

The hype around ChatGPT, OpenAI's viral AI-powered chatbot, hasn't reached a peak yet. That's the vibe one gets from Y Combinator's Winter 2023 batch, which features no fewer t

While some startups are reinventing the wheel, most are looking to build nuanced use cases of AI. It would be weirder if they weren't.

Y Combinator and Foundation Capital-backed meditation app Simple Habit has been acquired by Alpine Investors-backed wellness marketplace company Ingenio. Because of this deal, Simple Habit will rebran

Douwe Osinga and Jack Amadeo were working together at Sidewalk Labs, Alphabet's venture to build tech-forward cities, when they arrived at the conclusion that most spreadsheet software doesn't

Perhaps most of the move to multistage venture was simply predicated on interest rates being zero for so long.

Y Combinator will be writing fewer checks for late-stage companies, a scale back that also cost 17 team members — or roughly 20% of the accelerator's employees — their jobs, according to a s

Treasury secretary Janet Yellen said on Sunday that the U.S. Government would not bail out Silicon Valley Bank but is concerned about depositors reeling from what is the worst bank failure since the 2

Over 60 YC-backed Indian startups have more than $250,000 stuck in accounts with Silicon Valley Bank and nearly two dozen have more than $1 million tied with the lender, according to a survey by and a

Ken Van Haren and Chris Stanley were data scientists at Google and Square, respectively, who found themselves frustrated by how much time they were spending wrangling infrastructure versus doing actua

When people think of the funding crisis in further education, thoughts normally turn to the rising price of a typical four-year college degree. But that's not the only financial gap that exists:

Replicate, a startup that runs machine learning models in the cloud, today launched out of stealth with $17.8 million in venture capital backing; $12.5 million of the total came from a Series A led by

Due diligence was a big topic in 2022 for a variety of reasons. But due diligence doesn't just apply to investors pouring money into startups, or companies acquiring other companies. Businesses,

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Tesla Model Y Review

With a practical and reliable range, fast charging capabilities, plenty of space and user-friendly on-board technology, the Tesla Model Y will have no trouble appealing to buyers who need to take care of the family basics, but who also want the kerb appeal and badge kudos that Tesla provides at this point.

It's not perfect, though; the Model Y's two-tonne weight and lacklustre steering won't necessarily appeal to keener drivers, while its overly firm ride can be uncomfortable on the UK's less-than-perfect roads. The Model Y is still one to recommend, however, and despite a growing number of capable all-electric family SUV rivals, it's up there with the best EVs on sale today.

A few years ago, Tesla's Model 3 hatchback was the US firm's best-selling car in the UK, and it's not hard to see why when you consider its competitive pricing, exceptional range and great on-board technology. But, with the Model S saloon and Model X seven-seater SUV occupying the (much) more expensive top-end of the Tesla range, there was a definite niche waiting to be filled in the manufacturer's all-electric line-up. 

That's where the Tesla Model Y comes in. Essentially a bigger, more spacious Model 3, it should appeal to buyers looking for the extra practicality of an SUV, with all the technology and efficiency you'd expect of a Tesla. In fact, the Model Y has been a huge sales hit, finishing as the third best-selling car in the UK in 2022, behind the more traditional family favourites of the Nissan Qashqai and Vauxhall Corsa.

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Car group tests Road tests

After Tesla announced a price reduction across the Model Y range in January 2023, its mid-size family SUV now starts from around £45,000. That means the base rear-wheel drive version boasts a particular price advantage over the more premium entries in this class, namely the Audi Q4 e-tron, BMW iX3, Ford Mustang Mach-E and Mercedes EQB. Some equally family-friendly alternatives like the Hyundai Ioniq 5, Skoda Enyaq iV and Volkswagen ID.4 are more closely priced, as are the Nissan Ariya and Volvo XC40 Recharge.

Every Model Y offers an enticing blend of usable range and straight line performance; the base car gets a 283-mile range and 6.6-second 0-60mph time, while Tesla claims that the dual-motor Long Range version will cover up to 331 miles on a single charge, and the same 0-60mph dash in under five seconds.

Upgrading to the Model Y Performance brings a slight drop in range to 319 miles, with more than a second shaved from the benchmark sprint time. And, of course, you needn't fret about spending too long charging the battery, either – Tesla's Supercharger network will have you on your way in decent time, as a 0-80 per cent top-up takes less than half an hour.

It's typically minimalist inside the Model Y's cabin, with the large touchscreen taking centre stage and controlling most of the car's functions. There are no trim levels to choose from, just the three distinct variants; the base rear-drive Model Y, the dual-motor Model Y Long Range and the Model Y Performance, which also gets all-wheel drive. 

Standard kit includes LED headlights, alloy wheels, two-zone climate control, a panoramic glass roof, heated seats front and rear, adaptive cruise control with speed limit assist, 360-degree cameras and apps like Spotify, Netflix, Disney+, Twitch, YouTube built-in along with games and Tesla's toybox. The only options available are the five paint colours, black or white vegan upholstery, larger rims for the base and Long Range Model Y, and two more advanced versions of Tesla's Autopilot semi-autonomous driver-assistance system.

For an alternative review of the Tesla Model Y, visit our sister site drivingelectric.Com...

Mum: No End In Cannabis Fight After Latest Stop

A MUM fears there is "no end to the stress and trauma" of trying to get medical cannabis for her severely epileptic child after a second batch was seized as she re-entered the UK.

Emma Appleby hit the headlines when the medical cannabis oil she had bought in the Netherlands was seized by Border Force officials from her at Southend Airport in April.

The treatment, for her nine-year-old daughter Teagan, cost £4,600.

After that batch was seized, Ms Appleby and her partner Lee had to obtain a prescription from a specialist UK consultant to get it back.

But despite having that, the mum has been stopped again, having flown back to Gatwick from the Netherlands on Thursday carrying a month's supply of the drug.

She has been told she now needs an import licence.

Teagan suffers from a rare chromosomal disorder called Isodicentric 15 as well as Lennox-Gastaut syndrome, which causes up to 300 seizures a day.

Ms Appleby, from Aylesham near Dover, said: "There seems no end to the stress and trauma of trying to access the medical cannabis that I have proved beyond doubt transforms the life of my daughter Teagan.

"I am exhausted and shattered but I've seen how this medicine transforms my daughter's life.

"I have to find a way forward. The NHS just won't prescribe. This is unforgivably cruel and unfair."

Referring to the new need for an import licence, she added: "I believe that such a licence costs a lot of money. I am just a mum wanting to do the best for my child, not a company importing on a commercial basis."

The law in the UK was changed in November to make access to medical cannabis legal but parents have been struggling to secure prescriptions, in part due to reluctance within the medical community.

NHS guidance says cannabis-based products can "only be prescribed for indications where there is clear published evidence of benefit" and in "patients where there is a clinical need which cannot be met by a licensed medicine and where established treatment options have been exhausted".

Ms Appleby was accompanied by MP Tonia Antoniazzi, co-chair of the All-Party Parliamentary Group on Medical Cannabis under Prescription.

The Labour MP for Gower called on Health Secretary Matt Hancock to "get a grip of this and sort it out".

She added: "The implementation of this new policy is a shambles.

"Emma should not have to get a private prescription and have to cope with going abroad to get the medicine with all the bureaucracy this entails.

"She should be able to get it on the NHS.

"Emma has enough to do caring for her very sick daughter.

"It's unforgivable that parents like Emma are being passed from pillar to post like this."

A Government spokesman said: "It is unlawful to import unlicensed cannabis-based products for medicinal use to the UK without a Home Office importation licence.

"There is an established regulatory system which enables the importation of these products to the UK via pharmaceutical wholesalers, so they can be dispensed to UK resident patients prescribed these products by a specialist doctor.

"Border Force has a duty to enforce the law and stop the unlawful import of controlled substances into the UK."

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