Jewish Genetics: 75% of Jews Are Lactose Intolerant and 11 Other Facts
Targeted Genomics Announces Commercial Collaboration With OraSure Technologies For Direct To Consumer (DTC) Celiac Genetic Testing
Targeted GenomicsIRVINE, Calif., May 14, 2025 (GLOBE NEWSWIRE) -- Targeted Genomics LLC, developer of GlutenID, the first and only U.S. Food and Drug Administration (FDA) cleared direct-to-consumer (DTC) test for celiac disease genetics, today announced a commercial collaboration with OraSure Technologies, Inc. (NASDAQ: OSUR) manufacturer of ORAcollect®·Dx, the only FDA cleared saliva collection device for general over-the-counter (OTC) use. The collaboration expands consumer access to at-home celiac genetic testing.
Celiac disease, the most common intestinal autoimmune disease worldwide, is triggered by dietary gluten in people who carry the DQ2 and/or DQ8 celiac risk genes. Individuals who test negative for these genes have less than 1% chance for developing celiac disease during their lifetime. GlutenID assesses all 15 possible genetic combinations of the risk genes (GlutenIDs) using genomic DNA isolated from ORAcollect®·Dx saliva samples. Genetic results are reported within a spectrum of celiac disease risk. Identification of increased-risk individuals assists with diagnosis and prevention of celiac disease symptoms through informed adoption of a gluten free diet. GlutenID test users are encouraged to consult with a licensed healthcare provider or genetic counselor before making changes to their diet or lifestyle.
"The path to celiac disease diagnosis can be challenging for those who suffer with the symptoms," said Carrie Eglinton Manner, President and Chief Executive Officer, for OraSure Technologies, Inc. "This test allows for at-home collection of saliva samples, simplifying the testing process so patients can get actionable answers and, ultimately, relief. The ORAcollect®·Dx saliva collection device, with its FDA- clearance for prescription and over-the-counter use, integrates easily into the GlutenID test system, and we are proud to collaborate with Targeted Genomics to make celiac disease screening more accessible and convenient for at-risk individuals and their families."
"This new arrangement provides an opportunity for us to work with an experienced company in furthering our mission to provide wellness seeking consumers direct access to their genetic risk information," said Shelly Gunn MD PhD, Founder and Medical Director for Targeted Genomics, LLC. "Currently a lifelong gluten free diet is the only proven and effective therapy for prevention of potentially severe celiac disease complications including small bowel cancers."
Targeted Genomics and DNA Genotek, the subsidiary of OraSure Technologies that makes the ORAcollect®·Dx saliva collection device, have scheduled a joint webinar entitled "Insights from the development of a U.S. FDA cleared genetic health risk test" on May 21, 2025 at 1 p.M. EST. Registration information can be accessed with this link: https://www.Clinicallab.Com/insights-from-development-of-an-fda-cleared-genetic-health-risk-test-navigating-quality-and-compliance-in-the-evolving-regulatory-landscape-28253
Story Continues
GlutenID KitsAbout Targeted Genomics
Targeted Genomics, LLC develops testing solutions for inherited genetics and wellness through its affiliated College of American Pathologists (CAP) accredited and Clinical Laboratory Improvement Amendment (CLIA) certified molecular laboratory. The GlutenID test was designed to identify root causes of celiac disease through a gradient of genetic risk. For more information on Targeted Genomics, please visit www.Targeted-genomics.Com.
About OraSure Technologies
OraSure Technologies, Inc. ("OraSure") transforms health through actionable insight and powers the shift that connects people to healthcare wherever they are. OraSure improves access, quality, and value of healthcare with innovation in effortless tests and sample management solutions. OraSure, together with its wholly-owned subsidiaries, DNA Genotek Inc. And Sherlock Biosciences, Inc., is a leader in the development, manufacture, and distribution of rapid diagnostic tests and sample collection and stabilization devices designed to discover and detect critical medical conditions. OraSure's portfolio of products is sold globally to clinical laboratories, hospitals, physician's offices, clinics, public health and community-based organizations, research institutions, government agencies, pharmaceutical companies, and direct to consumers. For more information on OraSure Technologies, please visit www.Orasure.Com
A photo accompanying this announcement is available at https://www.Globenewswire.Com/NewsRoom/AttachmentNg/4e39b14d-8fdf-425d-b2c9-5c1ca14f8dba
CONTACT: Media Contact: Shelly Gunn MD, PhD shelly@targeted-genomics.Com
You Just Found Out You Have Celiac Disease—Here Are 7 Things Dietitians Say To Do First
Reviewed by Dietitian Jessica Ball, M.S., RD
Design elements: Getty Images. EatingWell design.
A celiac disease diagnosis can feel daunting and confusing as you learn to navigate the condition.
Nutrition experts weigh in on the seven things you should do first once you've been diagnosed.
Utilizing technology and focusing on foods you can eat are some of their top recommendations.
It is estimated that two million people in the United States have celiac disease, with many more individuals not yet diagnosed. Because symptoms can be nonspecific and they vary between individuals, receiving a celiac disease diagnosis can be challenging and time-consuming.
Celiac disease causes gastrointestinal distress and affects nutrient absorption. Treatment for celiac disease requires following a strict gluten-free diet. It can feel daunting to change your eating habits significantly, so we reached out to dietitians specializing in celiac disease to help guide you through this new diagnosis. Below, experts share the top seven things they recommend you do when first diagnosed with celiac disease.
What Is Celiac Disease?Celiac disease is an autoimmune condition triggered by eating foods containing gluten. It's a chronic condition that damages the small intestine, affecting both the digestive and immune systems. Gluten is a protein in grains like wheat, barley, rye and spelt. Many products—like pasta, couscous, bread and all-purpose flour—contain gluten. Consuming even a small amount of these gluten-containing foods can cause pain and stomach issues in people with celiac disease.
Celiac disease is different from gluten sensitivity or wheat intolerance. Although both conditions share symptoms, gluten sensitivity does not damage the small intestine. A wheat allergy and celiac disease both cause the immune system to react, but different symptoms may occur with a wheat allergy, including difficulty breathing and itchy eyes.
Finding out you have celiac disease and learning about the condition can be stressful and confusing. Dietitians explain what you should do to help manage a new diagnosis.
1. Make a List of Foods You Can EatRegistered dietitian Lauren Fleck, M.S., RD, encourages people with a new celiac diagnosis to make a list of gluten-free foods they enjoy eating. As someone living with celiac disease, Fleck understands how overwhelming a new celiac disease diagnosis can feel. "Focusing on what's allowed—like fruits, vegetables, meats, dairy, beans and naturally gluten-free grains—can shift your mindset from restriction to abundance."
Many carbohydrates are safe to eat with celiac disease. Potatoes and grains like amaranth, quinoa and rice are naturally gluten-free. Chickpea and lentil pasta are great gluten-free alternatives to wheat pasta, and they're also rich in protein.
2. Focus on SimplicityTransitioning to a gluten-free diet can feel overwhelming at first. "Sticking to naturally gluten-free foods is a helpful strategy while you become more confident navigating gluten-free labeling and ingredients," explains Lindsay Fencl, RD, CD.
Focus on simplicity by creating naturally gluten-free meals. Naturally gluten-free foods encompass most proteins (like chicken, fish, shellfish, meat, eggs and legumes), dairy, healthy fats, fruits and vegetables, including starchy vegetables like potatoes, sweet potatoes, butternut squash and corn. Create balanced meals by incorporating foods from each of these groups into meals.
3. Remember BROWSThe first step to eating with celiac disease is recognizing sources of gluten. Use the acronym BROWS to remember which grains contain gluten. The acronym BROWS stands for barley, rye, oats, wheat and spelt.
Although oats are gluten-free, they may be processed in facilities with wheat. Consider purchasing oats specifically labeled as gluten-free to avoid the risk of cross-contamination. Foods labeled gluten-free must contain less than 20 parts per million of gluten, below the threshold likely to cause symptoms in people with celiac disease.
4. Find a DietitianFind a dietitian who specializes in celiac disease to help you transition to a gluten-free lifestyle. "They'll help you learn how to avoid hidden sources of gluten, start the healing process and build a safe, balanced diet," explains Katie Schimmelpfenning, RD, LD, a sports nutrition expert and dietitian with celiac disease.
Additionally, registered dietitians can educate you on reading nutrition labels and help you identify sneaky sources of gluten. They also provide advice on dining out and supplements. A dietitian can be a trusted resource and advocate as you learn to live with celiac disease.
5. Prepare a Gluten Sick Day BoxYou'll likely accidentally eat gluten at some point, especially during your first year of living gluten-free. Schimmelpfenning recommends preparing a gluten sick day box with tools to help you feel better when you've been "glutened." As someone who has been managing celiac disease for over a decade, Schimmelpfenning stocks her gluten sick day box with a heating pad, electrolytes, peppermint tea, ginger chews, gluten-free plain crackers and gluten-free ramen.
Create your sick day kit based on your symptoms and items that provide comfort.
6. Learn Hidden Sources of Gluten and Avoid Cross-ContaminationLearning how to read labels is important. You may be surprised that many ingredients or additives contain gluten. Lisa Young, Ph.D., RD, notes, "Gluten isn't just in bread and pasta—it can lurk in sauces, salad dressings, soups and even medications and supplements." Malt, caramel, maltodextrin and modified food starch are some examples of sneaky sources of gluten.
Managing celiac disease requires more than just swapping gluten-containing foods for gluten-free options. Closely inspect your pantry and kitchen for potential cross-contamination. Toasters, cutting boards, baking trays and other items in your kitchen can be sources of cross-contamination. Consider purchasing a separate toaster for gluten-free products only. Implement a cleaning or labeling system to minimize the risk of cross-contamination.
7. Pack SnacksKeep gluten-free snacks on hand until you feel comfortable reading food labels when navigating grocery and convenience store aisles. Fleck recommends snacks like trail mix, jerky, applesauce or nuts—easy, shelf-stable options to keep in your bag for peace of mind when hunger strikes while you're on the go.
Other Tips for Managing Celiac DiseaseCeliac disease is a lifelong condition. The tips mentioned above help when you're first diagnosed, but other lifestyle modifications are just as essential for managing celiac disease.
Plan for social situations: Elyse Krawtz, M.S., RDN, recommends eating before events to prevent "hanger" that may lead to eating foods that could make you sick. Krawtz adds, "Submit food allergies at least a week or two in advance for formal or catered events. Gluten and wheat are common allergens and often chefs can accommodate with enough notice."
Create your support system: Family and friends can help you with eating at social occasions and dining out within a safe, gluten-free environment. Online support groups foster community and can help guide you through challenges that accompany living with celiac disease. Bess Berger, RDN, CDN, CLT, explains that support groups are places to share wins and swap recipes.
Use technology: Numerous apps exist to help you navigate a gluten-free lifestyle. Registered dietitian Ali McGowan, M.S., RD, LDN, recommends that individuals with celiac disease use apps to easily identify safe foods while grocery shopping. Other apps help with dining out and locating restaurants with gluten-free menus or dedicated fryers specific to gluten-free foods.
Have family members get tested: Celiac disease has a genetic component. If you have celiac disease, have your children, teens and other first-degree relatives tested, notes Gaby Thompson, M.S., RDN, LDN, dietitian and celiac family nutrition coach. First-degree relatives of someone with celiac disease have a one in 10 chance of developing the condition.
Limit ultra-processed gluten-free foods: Many popular convenience foods are available gluten-free. Young advises against relying on these ultra-processed gluten-free foods. "Many packaged gluten-free products are low in fiber and high in added sugar or fat," explains Young. She adds, "Use them occasionally, but prioritize naturally gluten-free options for overall health." Just because a product is labeled as gluten-free does not mean it is better for you.
Don't rely on symptoms to know your gluten tolerance: Some people with celiac disease may not notice symptoms after consuming some gluten. However, just because you don't experience symptoms doesn't mean the gluten isn't doing any harm. Krawtz explains, "Intestinal damage and production of pathogenic T cells after gluten consumption in individuals with celiac disease could still occur and increase risks, such as nutrient deficiencies, additional autoimmune diagnoses and cancers, even if symptoms are not noticeable." It's important that you limit your gluten intake and know that you may not notice symptoms if you're not eating large portions.
Shop new aisles: A celiac disease diagnosis does not have to feel like restriction or the end of eating as you know it. The key is finding gluten-free versions of foods you love. Fleck encourages people to explore the gluten-free section of the grocery store. "Trying different products can help you discover new staples while keeping your favorite meals in the mix," she adds.
A celiac disease diagnosis can feel overwhelming at first. But recognize that communities, resources and professionals exist to guide you through this new diagnosis and subsequent lifestyle changes. Utilizing technology, focusing on foods you can eat and learning how to identify gluten sources can help you manage life with celiac disease.
Read the original article on EATINGWELL
How Celiac Disease Affects The Body, And How To Manage It
Celiac disease is a serious autoimmune disorder that begins with something as small as a crumb of bread. Triggered by gluten—a protein found in wheat, barley, and rye—it causes the immune system to attack the small intestine, leading to inflammation and long-term complications if left untreated. This condition only develops in people with specific genetic markers (HLA DQ2 or DQ8) [1]. Although celiac disease affects 0.5% to 2% of the global population, it often remains undiagnosed, especially outside of Western countries [2].
Table of ContentsWhat Is Celiac Disease?In celiac disease, the immune system mistakes gluten for a threat and mounts an attack that damages the small intestine. This response causes villus atrophy, where the tiny finger-like projections (villi) responsible for nutrient absorption shrink and flatten [5], [7]. The result? Poor absorption of nutrients, which can lead to fatigue, digestive distress, anemia, and more.
The only treatment is a strict gluten-free diet. With careful planning and label-reading, people with celiac disease can manage their symptoms and prevent complications.
Genetics and the Immune ResponseYou need to carry the HLA DQ2 or DQ8 genes to develop celiac disease [3], [13], but not everyone with these genes gets sick. Think of these genes as the "key"—they open the door, but you still have to walk through it. These genetic markers are also linked to other autoimmune disorders, increasing the risk of overlapping conditions.
When gluten is consumed, the immune system produces inflammatory cells and antibodies that attack the intestinal lining. This ongoing inflammation impairs digestion and can lead to widespread issues, including bone weakness and nutrient deficiencies.
The World Journal of Gastrointestinal Pathophysiology notes, "villous atrophy fundamentally disrupts normal digestion and absorption, resulting in multi-organ impacts" [7].
Common SymptomsCeliac disease doesn't look the same for everyone. Symptoms can be obvious or silent:
Digestive symptoms may include:
Non-digestive symptoms might include:
Some people have no gut issues at all, but still suffer internal damage. That's why antibody testing—like the anti-tissue transglutaminase (anti-tTG) test—is vital for diagnosis [4], [6], [8].
American Family Physician explains that "serologic testing has revolutionized early detection, even in minimally symptomatic patients" [8].
How Celiac Disease Is DiagnosedDiagnosis involves a multi-step process:
The American Journal of Gastroenterology notes, "genetic testing is particularly valuable when the diagnosis remains uncertain" [13].
Untreated celiac disease can lead to:
Celiac disease is also linked with other autoimmune disorders like type 1 diabetes and rheumatoid arthritis. Some patients may develop refractory celiac disease, where symptoms persist despite a gluten-free diet. Others may experience conditions like lactose intolerance or irritable bowel syndrome as coexisting issues. [9]
Treatment: A Gluten-Free Diet for LifeThere's no cure—just one proven treatment: a strict, lifelong gluten-free diet[6], [10], [11]. This means:
Most people feel better within weeks, though full healing may take months or years depending on severity and age at diagnosis [5]. Regular check-ups and guidance from a dietitian can help ensure nutritional balance.
American Family Physician states, "patients benefit from ongoing nutritional counseling to optimize long-term outcomes" [6].
Foods to AvoidGluten is found in:
Reading labels is critical. Avoiding even trace amounts of gluten is essential to prevent symptoms and long-term damage.
Eating Out with Celiac DiseaseDining out can be tricky, but not impossible. Many restaurants now offer gluten-free options. Ask about preparation methods and cross-contamination risks. Carry a gluten-free dining card to help explain your needs. With planning, eating out can still be safe and enjoyable.
Celiac Disease and Other Autoimmune ConditionsHaving celiac disease raises the risk of developing other autoimmune disorders like autoimmune thyroid disease and type 1 diabetes. This is due to shared genetic and immune system triggers. Managing celiac disease with a gluten-free diet not only improves gut health but may help reduce systemic inflammation and lower the risk of additional autoimmune issues.
Final ThoughtsCeliac disease is a genetic autoimmune condition that causes intestinal and systemic damage when gluten is consumed. Its symptoms vary widely—from digestive problems to silent nutrient deficiencies—but the path forward is clear: early diagnosis, followed by lifelong gluten avoidance. With commitment and proper medical guidance, people with celiac disease can lead healthy, vibrant lives.
References[1] Lindfors, K., Ciacci, C., Kurppa, K., Lundin, K. E. A., Makharia, G. K., Mearin, M. L., Murray, J. A., Verdu, E. F., & Kaukinen, K. (2019). Coeliac disease. Nature reviews. Disease primers, 5(1), 3. Https://doi.Org/10.1038/s41572-018-0054-z
[2] Catassi, C., Verdu, E. F., Bai, J. C., & Lionetti, E. (2022). Coeliac disease. Lancet (London, England), 399(10344), 2413–2426. Https://doi.Org/10.1016/S0140-6736(22)00794-2
[3] D'Avino, P., Serena, G., Kenyon, V., & Fasano, A. (2021). An updated overview on celiac disease: from immuno-pathogenesis and immuno-genetics to therapeutic implications. Expert review of clinical immunology, 17(3), 269–284. Https://doi.Org/10.1080/1744666X.2021.1880320
[4] Green, P. H., Lebwohl, B., & Greywoode, R. (2015). Celiac disease. The Journal of allergy and clinical immunology, 135(5), 1099–1107. Https://doi.Org/10.1016/j.Jaci.2015.01.044
[5] Rubin, J. E., & Crowe, S. E. (2020). Celiac Disease. Annals of internal medicine, 172(1), ITC1–ITC16. Https://doi.Org/10.7326/AITC202001070
[6] Pelkowski, T. D., & Viera, A. J. (2014). Celiac disease: diagnosis and management. American family physician, 89(2), 99–105. Https://pubmed.Ncbi.Nlm.Nih.Gov/24444577/
[7] Parzanese, I., Qehajaj, D., Patrinicola, F., Aralica, M., Chiriva-Internati, M., Stifter, S., Elli, L., & Grizzi, F. (2017). Celiac disease: From pathophysiology to treatment. World journal of gastrointestinal pathophysiology, 8(2), 27–38. Https://doi.Org/10.4291/wjgp.V8.I2.27
[8] Williams, P. M., Harris, L. M., DO, & Odom, M. R. (2022). Celiac Disease: Common Questions and Answers. American family physician, 106(1), 36–43. Https://pubmed.Ncbi.Nlm.Nih.Gov/35839368/
[9] Lebwohl, B., Ludvigsson, J. F., & Green, P. H. (2015). Celiac disease and non-celiac gluten sensitivity. BMJ (Clinical research ed.), 351, h4347. Https://doi.Org/10.1136/bmj.H4347
[10] Selimoğlu, M. A., & Karabiber, H. (2010). Celiac disease: prevention and treatment. Journal of clinical gastroenterology, 44(1), 4–8. Https://doi.Org/10.1097/MCG.0b013e3181b7ead2
[11] Leonard, M. M., Sapone, A., Catassi, C., & Fasano, A. (2017). Celiac Disease and Nonceliac Gluten Sensitivity: A Review. JAMA, 318(7), 647–656. Https://doi.Org/10.1001/jama.2017.9730
[12] Villanacci, V., Vanoli, A., Leoncini, G., Arpa, G., Salviato, T., Bonetti, L. R., Baronchelli, C., Saragoni, L., & Parente, P. (2020). Celiac disease: histology-differential diagnosis-complications. A practical approach. Pathologica, 112(3), 186–196. Https://doi.Org/10.32074/1591-951X-157
[13] Brown, N. K., Guandalini, S., Semrad, C., & Kupfer, S. S. (2019). A Clinician's Guide to Celiac Disease HLA Genetics. The American journal of gastroenterology, 114(10), 1587–1592. Https://doi.Org/10.14309/ajg.0000000000000310
MORE DOCTORS & SCIENTISTS
Comments
Post a Comment